Day 1, Sunday, September 22, 2019         

7:00 am - 8:15 am         Registration & Breakfast

8:15 am - 8:30 am         Opening Remarks & Welcome by conference chair Daniel Anderson, MIT


Session 1          Chairs: Bing Xu (Brandeis Univ) & Rajagopal Ramesh (OUHSC)


8:30am - 9:00 am:         Electrostatic Nanoparticle Platforms for Deep Tissue Penetration and Delivery   

Paula Hammond, David H. Koch Professor in Engineering, MIT


9:00 am - 9:30 am         Bioengineered silk-elastin systems for biomedical utility

David Kaplan, Stern Family Professor of Biomedical Engineering, Tufts University


9:30 am -10:00 am        New delivery vehicles for gene editing enzymes

Niren Murthy,   Professor of Bioengineering, University of California at Berkeley


10:00 am - 10:30 am     Coffee Break


10:30 am - 11:00 am      Engineering the activation of natural and synthetic T cells with nanomaterials

Darrell Irvine, Professor of Materials Science & Engineering and Biological Engineering,  MIT


11:00 am - 11:30 am      Engineering exosomes to create transformative drugs

Tony De Fougerolles​, CEO, Evox Therapeutics


11:30 am - 12:00 pm     Development of a Platform for Exosome Engineering and Large-Scale Manufacturing

Konstantin Konstantinov, Executive Vice President, Codiak BioSciences


12:00 pm - 1:30 pm       Lunch Break & Poster Session


Session 2          Chairs: Haiquan Mao (JHU) & Yizhou Dong (Ohio State Univ) & Arturo Vegas (BU)


1:30 pm - 2:00 pm         Macrophage Reprogramming with Nano-Delivery for Cancer and Inflammatory Diseases

Mansoor Amiji, University professor, Northeastern University


2:00 pm - 2:30 pm         Avoiding the endosomal trap: Direct cytosolic delivery of proteins (including CRISPR/Cas9) through membrane fusion processes

Vincent Rotello, Charles A. Goessmann Professor of Chemistry, University of Massachusetts at Amherst


2:30 pm - 3:00 pm         Polymeric Nanoparticles for Intracellular Delivery and Cellular Programming

Jordan Green, Professor of Biomedical Engineering, Johns Hopkins University School of Medicine


3:00 pm - 3:30 pm         Coffee Break



3:30 -pm - 4:00 pm        HiFi molecular transmission via crisscross cooperativity

 William Shih, Professor, Wyss Institute/Harvard Medical School


4:00 pm - 4:30 pm         Modulating inflammation with nanoparticle payloads

Matthias Nahrendorf, Professor of Radiology, MGH/Harvard Medical School


4:30 pm - 5:00 pm         Non-invasive drug and gene delivery to the brain

Justin Hanes, Lewis J. Ort Professor of Ophthalmology, Johns Hopkins University School of Medicine


5:00 pm -5:30 pm         Ultra-high capacity polymeric micelles for drug delivery

Alexander Kabanov, the Mescal S. Ferguson Distinguished Professor, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill


5:30 pm – 7:30 pm        Welcome Reception

Day 2, Monday, September 23, 2019         



7:00 am - 8:15 am         Registration & Breakfast


Session 3          Chairs: Akin Akinc (Alnylam) & Phil Snyder (Vertex)     


8:15 am - 8:45 am         From Microtechnology to Nanotechnology: New Ways to Discover and Deliver Medicine to Treat Disease

Robert Langer, Institute Professor, MIT


8:45 am - 9:15 am         In Vivo CRISPR Gene Editing by Lipid Nanoparticles

Andrew Schiermeier, Chief Operating Officer, Intellia Therapeutics


9:15 am -9:45 am          Coffee Break


9:45 am - 10:15 am       Breaking the Druggability Barrier using Helicons

Gregory Verdine, Chairman; President and CEO, Fog Pharma


10:15 am - 10:45 am     Gene editing therapies for inherited retinal diseases

Charlie Albright, Chief Scientific Officer, Editas Medicine


10:45 am - 11:15 am     Applications of Nanosensors to Understanding Biochemical Signaling Within the Human Body

Michael Strano, Carbon P. Dubbs Professor in Chemical Engineering, MIT


11:15 am - 11:45 am     Pioneering new medicinal platforms for targeted delivery – an ecosystem view

Noubar Afeyan, Founder & CEO, Flagship Pioneering


11:45 am - 1:30 pm       Lunch Break & Poster Session


Session 4          Chairs: Daniel Anderson (MIT) & Sekar Kathiresan (Verve Tx) & Shawn Chen (NIH)


1:30 pm - 2:00 pm         The New Science of Therapeutics - Advanced Therapeutic Platforms

Jay Bradner, President, Novartis Institutes for BioMedical Research (NIBR)


2:00 pm - 2:30 pm         Advances in RNAi Therapeutics Platform

Vasant Jadhav, Vice President, Alnylam Pharmaceutics


2:30 pm - 3:00 pm         Advancing the delivery of LNP-encapsulated mRNA therapeutics for the treatment of genetic diseases

Ronald C. Renaud Jr., Chief Executive Officer, Translate Bio


3:00 pm - 3:30 pm         Industrialization of mRNA medicines

Stéphane Bancel, Chief Executive Officer, Moderna Inc.


3:30 -pm - 4:00 pm        coffee break


4:00 pm - 4:30 pm         Activity-based nano sensors as synthetic biomarkers of disease

Sangeeta Bhatia, John J. and Dorothy Wilson Professor of Engineering, MIT


4:30 pm - 5:00 pm         Bringing CRISPR to the clinic

Tony Ho, Executive Vice President, CRISPR Therapeutics


5:00 pm – 7:30 pm        Networking Event

Day 3, Tuesday, September 24, 2019         


7:00 am - 8:15 am         Registration & Breakfast


Session 5          Late Breaking Topics/Selected Posters

Chairs: Omid Veiseh (Rice Univ) & Michael Mitchell (UPenn)


8:15 am – 8:30 am A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing

Shaoqin (Sarah) Gong, Vilas Distinguished Professor, Department of Biomedical Engineering, University of Wisconsin Madison


8:30 am - 8:45 am Steric stabilization of protein-based nanostructures using elastin-like polypeptides

J. Andrew MacKay, Gavin S. Herbert Associate Professor of Pharmaceutical Sciences, School of Pharmacy, University of Southern California


8:45am – 9:00am  Intelligent Nanomaterials for Gene, Drug and Nitric Oxide Delivery

Won Jong Kim, Mueunjae Chaired Professor, Department of Chemistry, Pohang University of Science and Technology (POSTECH), South Korea


9:00 am – 9:15 am  Biodegradable Nanoparticles for CRISPR/Cas9 Genome Editing Delivery

Ming Wang, Professor, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China


9:15 am – 9:30 am Scalable Manufacture of mRNA Lipid Nanoparticles Using a Novel Microfluidic Mixing Architecture
Pratik Goswami, Precision NanoSystems Inc., Vancouver, BC, Canada.


9:30 am - 9:45 am Discovery of Small Anti-PD-L1 Peptides for Cancer Immunotherapy.

Kun Cheng, Curators' Distinguished Professor, Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City


9:45 am – 10:10 am      Coffee Break


10:10 am-11:30 am       Poster Presenters  (Moderator: Gaurav Sahay (Oregon State Univ))


Session 6          Closing Session


Chair: Qiaobing Xu (Tufts Univ)


11:30 am – 12:00 pm     Nanoparticle medicated delivery for inner ear applications

Zhengyi Chen, Associate Professor of Otolaryngology, Massachusetts Eye and Ear/MGH


12:00 pm - 12:30 pm     Helping biological drugs to reach their targets

Maria José Alonso, Professor of Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Spain


12:30 pm - 12:35 pm     Closing remarks by conference chair Qiaobing Xu, Tufts University